Pazopanib Hcl (Votrient)

Alternate Name: Votrient

Dosage Form: Tablet

Administration Route: By mouth

Drug Class: Antineoplastic Agent, Immunological Agent

Generic Available: Yes

Strength: 200 MG

Warnings: Keep all medicine out of the reach of children. Never share your medicine with anyone. Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Men and women should use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 2 weeks after your last dose. Do not breastfeed while you are using this medicine and for 2 weeks after the last dose. Tell your doctor if you have kidney disease, liver disease (including Gilbert syndrome), heart disease, high blood pressure, lung disease, stomach or bowel problems, thyroid problems, or a history of heart rhythm problems (including QT prolongation), heart attack, or stroke. Tell your doctor if you had any bleeding problems in the last 6 months, including stomach or bowel bleeding. This medicine may cause the following problems:Severe liver problemsChanges in heart rhythm, including QT prolongation, Torsades de pointesHeart failure, high blood pressure, heart attack, or strokeBleeding problemsIncreased risk of blood clotsInterstitial lung disease or pneumonitis, which may be life-threateningStomach or bowel problems (including perforation, fistula)Reversible posterior leukoencephalopathy syndrome (RPLS)High blood pressureHypothyroidism (underactive thyroid)Kidney problemsTumor lysis syndromeSerious infections This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. Tell any doctor who treats you that you are using this medicine. This medicine may affect the way your body heals from cuts and wounds. You may need to stop using it at least 7 days before you have surgery. Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Food Warnings: Some foods and medicines can affect how pazopanib works. Tell your doctor if you are using any of the following:Bevacizumab, clarithromycin, ketoconazole, lapatinib, pemetrexed, rifampin, ritonavir, simvastatin, topotecanMedicine for heart rhythm problemsStomach medicine (including esomeprazole), Take antacids several hours before or after you take pazopanib., Do not eat grapefruit or drink grapefruit juice while you are using this medicine., Tell any doctor who treats you that you are using this medicine. This medicine may affect the way your body heals from cuts and wounds. You may need to stop using it at least 7 days before you have surgery., Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it., Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will need to have your blood pressure measured before you start this medicine and while you are using it., Keep all medicine out of the reach of children. Never share your medicine with anyone.